Lucky kindlin: A cloverleaf at the integrin tail
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چکیده
منابع مشابه
Lucky kindlin: A cloverleaf at the integrin tail.
In a paper published in PNAS, Li et al. (1) solve the long-awaited crystal structure of kindlin-2, which plays a central role in integrin activation, clustering, and signaling (2, 3). Integrins are a large family of heterodimeric adhesion molecules composed of αand β-subunits and expressed on almost all cells. They mediate cell matrix adhesion by binding extracellular matrix proteins, such as c...
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Increased ligand binding to cellular integrins ("activation") plays important roles in processes such as development, cell migration, extracellular matrix assembly, tumor metastasis, hemostasis, and thrombosis. Integrin activation encompasses both increased integrin monomer affinity and increased receptor clustering and depends on integrin-talin interactions. Loss of kindlins results in reduced...
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Integrins are essential adhesion receptors found on the surfaces of all metazoan cells. As regulators of cell migration and extracellular matrix assembly, these membrane-spanning heterodimers are critical for embryonic development, tissue repair and immune responses. Signals transmitted by integrins from outside to inside the cell promote cell survival and proliferation, but integrin affinity f...
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Platelet agonists increase the affinity state of integrin a IIb b 3 , a prerequisite for fibrinogen binding and platelet aggregation. This process may be triggered by a regulatory molecule(s) that binds to the integrin cytoplasmic tails, causing a structural change in the receptor. b 3 -Endonexin is a novel 111–amino acid protein that binds selectively to the b 3 tail. Since b 3 -endonexin is p...
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Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic inte...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1712471114